Calculate a Lyophilization Cycle
Fill out the form below and follow the directions. Replace the values given with values you know.
% Solids in the Formula: Include all excipients and actives (except water).
The actual fill volume in mL.
Pick the vial type and size.
Tg' or Collapse Temperature in °C
Tp, the Safe Ice Temperature should be 2 or 3 degrees less than the collapse Temperature.
Chamber Pressure to Use - The value is a recommendation based on Tp. Any pressure between 0 and 200 mtorr can be used.
'Recalc' goes back to the recommendation.
= Shelf Temp
Vary the Shelf Temperature until Tp
and the Temperature at the Top of the Ice
match to within 0.5°C.
Average value for Product resistance in torr*cm
*hr/gm. Recalc returns the recommendation.
change in Temperature over a 1cm height of the ice.
Temperature at the top of the ICE.
Click in the Box to get a Calculation.
Calculate a primary dry time.
minutes in primary at conditions above: Safety factor = 1.5.
Start Temp = 18°C
Ramp Rate going to Temp
Hold Time at Temp