-
Sublimation rates are a prime consideration when moving a cycle from
one lyophilizer to another.
-
Drying rate is affected by different dryer design and function. Often the
new lyophilizer will not execute exactly the same sequence of steps as the
original or it may need changes in the PLC ladder
logic.
-
Condenser efficiency versus thermal load will vary
the rate and quality of the sublimation.
-
Freezing
conditions or super cooling differences may change the water
crystallization characteristics and lead to fundamental changes in the
product lyophile.
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